DHA and nervous system health

The potential of omega-3 fatty acids in the nervous system health is having an increasing interest. Fossil studies in Africa have shown that skulls from savanna inhabitants (were the main food sources were meat and grasses), were smaller in size to those found in coastal areas (were seafood was also part of the diet). These observations lead to the working hypotheses that introduction of omega-3 in the diet and especially of DHA, was the turning point in the evolution which lead towards a rational and intelligent human being. Up to 50-60% of the brain’s weight are lipids (fats) from which 35-40% are DHA, with hardly no EPA (<1%). Therefore, from a structural viewpoint, DHA is with no doubt the key omega-3 fatty acid in the brain.

DHA is a ‘raw material’ needed for the formation of the neuronal network (‘electric cabling in the brain’) and its intake increases the speed at which the nervous impulse is transmitted (of great interest in concentration alterations). In addition, DHA (and possibly to some extent EPA) seem to be involved in the modulation of several neurotransmitters (ie. serotonin, dopamine etc), being a nutrient of great interest in many neurological and neuropsychiatric disorders.

  • Crawford M, Bloom M, Broadhurst CL.(1999) Evidence of the unique function of docosahexaenoic acid during the evolution of the modern hominid brain. Lipids 34: S39-S47.
  • Crawford MA et al., (2008) The role of Docosahexaenoic and Arachidonic acids as determinants of evolution and hominid brain development. Fisheries fro Global Welfare and Environment, 5th World Fisheries Congress pp.57-76
  • Lagercrantz H, Ringstedt T (2001) Organization of the neuronal circuits in the central nervous system during developing. Acta Paediatr 90: 707-715.
  • Lauritzen L, Hansen HS, Jurgensen MH, Michaelsen KF (2001)The essentiality of long-chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 40: 1-94.
  • Travis J. (1994) Wiring the nervous system. Science 266: 568-570.
  • Wu A, Ying Z, Gomez-Pinilla F (2008) Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience 155(3):751-9.